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Recent Publications

Ferrer-Acosta, Y., Rodríguez-Cruz, E.N., Orange, F., De Jesús-Cortés, H., Madera, B., Vaquer-Alicea, J., Ballester, J., Guine,l M.J., Bloom, G.S., and Vega, I.E., (2013), EFhd2 is a novel amyloid protein associated with pathological tau in Alzheimer's disease. J Neurochem. Jun;125(6):921-31. doi: 10.1111/jnc.12155. Epub 2013 Feb 14. Pubmed icon

 

Fasoli, E., Reyes, Y.R., Guzman, O.M., Rosado, A., Cruz, V.R., Borges, A., Martinez, E., and Bansal, V. (2013), Para-aminobenzamidine linked regenerated cellulose membranes for plasminogen activator purification: effect of spacer arm length and ligand density. J Chromatogr B Analyt Technol Biomed Life Sci. Jul 1;930:13-21. doi: 10.1016/j.jchromb.2013.04.025. Epub 2013 Apr 24. Pubmed icon

 

Grajales-Reyes, G., Baez-Pagan, C.A., Zhu, H., Grajales-Reyes, J.G., Delgado-Vélez, M., García-Beltrán, W.F., Luciano, C.A., Quesada, O., Ramírez, R., Gómez, C.M., and Lasalde-Dominicci, J.A., (2012), Transgenic mouse model reveals an unsuspected role of the acetylcholine receptor in statin-induced neuromuscular adverse drug reactions. The Pharmacogenomics Journal (Nature Publishing Group), Advanced Online Publication, 12 June 2012, doi:10.1038/tpj.2012.21 Pubmed icon Nature Publishing Group logo

 

Gaudier-Pagán, J.F., Cabán-Hernández, K., Osuna, A.,and Espino, A.M., (2012), Biochemical characterization and differential expression of a 16.5 kDa tegument-associated antigen from the liver fluke Fasciola hepatica. Clin. Vaccine Immunol., 19(3), 325-333. Pubmed icon

 

Rivera-Rivera, L., Pérez-Laspiur, J., Colón, K., and Meléndez, L.M., (2012) Inhibition of interferon response by cystatin B: implication in HIV replication of macrophage reservoirs. J. Neurvirol., Feb;18(1):20-9. Pubmed icon Download PDF

 

Ballester, L.Y., Capo-Velez, C.M., Garcia-Beltran, W.F., Ramos, F.M., Vazquez-Rosa, E., Rios, R., Mercado, J.R., Melendez, R.I. and Lasalde-Dominicci, J.A. (2011) Up-regulation of the neuronal nicotinic receptor α7 by HIV-GP120: potential implications for HIV associated neurocognitive disorder. J. Biol. Chem., 10.1074/jbc.M111.262543. pubmed icon download pdf

 

Pasten, C., Ortiz-Pineda, P.A. and E García-Arrarás, J. (2011) Ubiquitin-proteasome system components are up-regulated during intestinal regeneration. Genesis, 10.1002/dvg.20803. pubmed icon

 

Salgado, I.K., Serrano, M., García, J.O., Martínez, N.A., Maldonado, H.M., Báez-Pagán, C.A., Lasalde-Dominicci, J.A. and Silva, W.I. (2011) SorLA in Glia: Shared Subcellular Distribution Patterns with Caveolin-1. Cell. Mol. Neurobiol., 10.1007/s10571-011-9771-5. pubmed icon

 

Padilla-Morales, L.F., Morales-Pérez, C.L., De La Cruz-Rivera, P.C., Asmar-Rovira, G., Báez-Pagán, C.A., Quesada, O. and Lasalde-Dominicci, J.A. (2011) Effects of Lipid-Analog Detergent Solubilization on the Functionality and Lipidic Cubic Phase Mobility of the Torpedo californica Nicotinic Acetylcholine Receptor. J. Membr. Biol., 243, 47-58. pubmed icon

 

Mashanov, V.S., Zueva, O.R. and Garcia-Arraras, J.E. (2010) Organization of glial cells in the adult sea cucumber central nervous system. Glia, 58, 1581-1593. pubmed icon

 

López-Hernández, G.Y., Biaggi-Labiosa, N.M., Torres-Cintrón, A., Ortiz-Acevedo, A. and Lasalde-Dominicci, J.A. (2009) Contribution of position alpha4S336 on functional expression and up-regulation of alpha4beta2 neuronal nicotinic receptors. Cell. Mol. Neurobiol., 29, 41-53. pubmed icon

 

Báez-Pagán, C.A., Martínez-Ortiz, Y., Otero-Cruz, J.D., Salgado-Villanueva, I.K., Velázquez, G., Ortiz-Acevedo, A., Quesada, O., Silva, W.I. and Lasalde-Dominicci, J.A. (2008) Potential role of caveolin-1-positive domains in the regulation of the acetylcholine receptor’s activatable pool: implications in the pathogenesis of a novel congenital myasthenic syndrome. Channels (Austin), 2, 180-190. pubmed icon download pdf

 

López-Hernandez, G. Y., Sanchez-Padilla, J., Ortiz-Acevedo, A., Lizardi-Ortiz, J., Salas-Vincenty, J., Rojas, L. V., and Lasalde-Dominicci, J. A. (2004) Nicotine-induced up-regulation and desensitization of alpha4beta2 neuronal nicotinic receptors depend on subunit ratio, J. Biol. Chem., 279, 38007-38015. pubmed icon download pdf

 

Santiago, J., Guzmàn, G.R., Rojas, L.V., Marti, R., Asmar-Rovira, G.A., Santana, L.F., McNamee, M. and Lasalde-Dominicci, J.A. (2001) Probing the effects of membrane cholesterol in the Torpedo californica acetylcholine receptor and the novel lipid-exposed mutation alpha C418W in Xenopus oocytes. J. Biol. Chem., 276, 46523-46532. pubmed icon download pdf

 

POSTERS PRESENTATIONS

I Salgado1, M.Serrano, N Martínez, J.O. García, H.Maldonado, Carlos Baéz-Pagán, José Lasalde-Dominicci, W. Silva. SorLA and caveolin-1 shared subcellular distribution patterns in glia – 19th Puerto Neurosciences Conference, Centro de Estudios Avanzados, San Juan, Puerto Rico, December 2009

I Salgado, H.M. Maldonado, C. Baez-Pagan, J.A. Lasalde-Dominicci, W.I. Silva. Putative overlapping motif mediating SorLA: caveolin-1 interaction in glia – 10th International Conference on Alzheimer's & Parkinson's Diseases Barcelona, Spain March 9, 2011

I Salgado, M. Serrano, N Martínez, J.O. García, H.Maldonado, Carlos Baéz-Pagán, José Lasalde-Dominicci, W. Silva. SorLA in glia: a partner of cav-1 - RISE Retreat Verdanza Hotel Carolina, Puerto Rico March, 2011- 1st  Congress of Physiological Sciences February 4, 2011

I Salgado, M. Serrano, N Martínez, J.O. García, H.Maldonado, Carlos Baéz-Pagán, José Lasalde-Dominicci,W. Silva. SorLA is a membrane raft protein in glial cells – Puerto Rico Neuroscience’s Conference Interamerican University, Bayamón P.R. December 4, 2010 - Experimental Biology Anaheim California April 2010

Gaudier, J., Caban-Hernandez, K., Espino A.M.Biocehmical characterization and differential expression of a 16.5kDa tegument antigen from the liver fluke Fasciola hepatica. – ASM 111th General Meeting, Ernest M. Morial Convention Center N.O.  May 21-34, 2011.

Padilla-Morales LF, Morales-Pérez CL, De La Cruz-Rivera PC, Asmar-Rovira G, Báez-Pagán CA, Quesada O, Lasalde-Dominicci JA. Effects of Lipid-Analog Detergent Solubilization on the Functionality and Lipidic Cubic Phase Mobility of the Torpedo californica Nicotinic Acetylcholine Receptor. - Biophysical Society 55th  Annual meeting, Baltimore, Maryland 2011-Biophysical Society 56th Annual meeting, San Diego, California 2012- ABRCMS Annual Biomedical Research Conference for Minority Students, St. Louis, Missouiri 2011. 43rd IUPAC World Chemistry Congress. July 31-August 5, 2011 at San Juan, Puerto Rico

Delgado-Vélez, M., Carrasquillo, O., Emmanuelli, L., Madera, B., Gomez, C. and Lasalde-Dominicci, José. Alcohol promotes kinetic alterations on acetylcholine receptors in a model of slow-channel congenital myasthenic syndrome. 29th Puerto Rico Interdisciplinary Scientific Meeting, San Juan, Puerto Rico, March, 2009. Society for Neuroscience, Chicago, October, 2009.

Grajales, G., Baez, C.A., Delgado, M., Ramirez, R., Gomez, C., Lasalde-Dominicci, J. Lipid-protein interactions studies in the αC418W slow channel congenital myasthenic syndrome. Society for Neuroscience, Chicago, October, 2009.

Grajales-Reyes, G., Haipeng, Z., Baez-Pagan, C., Quesada, O., Grajales-Reyes, J., Delgado- Vélez, M., Ramirez, R., Gomez, C., Lasalde-Dominicci. In vivo lipid-protein characterization of the αC418W Slow Channel Congenital Myasthenic Syndrome. 8th Annual Puerto Rico Neuroscience Conference, Ponce School of Medicine, December 5, 2009. 

Ortiz, D., C, Ortiz, D., P, Rivera, E, Delgado, V., M., Ramírez, R., Gomez, C., Lasalde-Dominicci, J. Alcohol exacerbates the neuromuscular degeneration in δS262T a transgenic mice expressing the Slow-Channel Congenital Myasthenic Syndrome. 30th Puerto Rico Interdisciplinary Scientific Meeting (PRISM), University of Puerto Rico, Mayaguez, March, 2010.

Capó-Vélez, C.C., Montes-Santiago, E., Delgado-Vélez, M., Lasalde-Dominicci, J.A. Up-regulation of α7-nicotinic acetylcholine receptors by HIV-1 gp120 implications in the pathogenesis of HIV-associated dementia. 8th Conference of the Specialized Neuroscience Research Programs, Caribe Hilton, San Juan, Puerto Rico, July 21-23, 2010.

Santiago-Pérez, L.I., Delgado-Vélez, M., Baez-Pagan, C., Ballester, L.Y., Meléndez, L., Wojna,V., Serrano, M., García, V., Gerena-López, Y., Delgado, F.Y., Capó-Vélez, C., Silva, W., Lasalde-Dminicci, J.A. HIV-gp120 signaling via α7 nicotinic acetylcholine receptor: implications in the pathogenesis of HIV infection. 8th Conference of the Specialized Neuroscience Research Programs, Caribe Hilton, San Juan, Puerto Rico, July 21-23, 2010.

Grajales-Reyes, G.E., Baez-Pagán, C., Grajales- Reyes, J.G., Zhu, H., Delgado-Vélez, M., Quesada, O., Gomez, C., Ramirez, R., Lasalde-Dominicci, J. Uncovering the molecular basis for collateral effects of statins in the NMJ of αC418W mice. 8th Conference of the Specialized Neuroscience Research Programs, Caribe Hilton, San Juan, Puerto Rico, July 21-23, 2010. 

Capó-Vélez, C., Santiago-Montes, E., Delgado-Vélez, M., Melendez, R.I., Lasalde-Dominicci, J.A., The alpha7 acetylcholine receptor is up-regulated in a transgenic mouse model that expresses the HIV-1 coat protein gp120: potential implications in the pathogenesis of HIV-1 associated dementia. 10th International Symposium on NeuroVirology, Milan, Italy, October 12-16, 2010.

Delgado-Vélez, M., Báez-Pagan, C., Santiago-Perez, L.I., Ballester, L.Y., Quesada, O., Vazquez, E., Serrano, M., García, V., Gerena-Lopez, Y., Wojna, V., Delgado, F.Y., Capó-Vélez, C., Santana, O. Lasalde-Dominicci, J. HIV-1 gp120 up-regulates α7 nicotinic acetylcholine receptor in monocyte-derived macrophages. 10th International Symposium on NeuroVirology, Milan, Italy, October 12-16, 2010.

Delgado-Vélez., Báez-Pagán, C., Santiago-Pérez, L.I., Ballester, L.Y., Quesada, O., Vazquez. E., Serrano, M., García, V., Gerena-López, Y., Wojna, V., Delgado, F.Y., Ramirez, N.L., Capó-Vélez, C., Santana, O., Melendez, L., Silva, W., Lasalde-Dominicci, J.A. HIV-1 gp120 increase α7 nicotinic acetylcholine receptor in monocytes-derived macrophages: a new perspective in HIV infection. 19th Annual Puerto Rico Neuroscience Conference, Interamerican University, PR, December 4, 2010.

Delgado-Vélez., Báez-Pagán, C., Quesada, O., Vazquez. E., Santiago-Pérez, L.I., Wojna, V., Gerena-López, Y., Melendez, L., Silva, W., Lasalde-Dominicci, J.A. HIV-1 envelope gp120 induce upregulation and signaling through the α7 nicotinic acetylcholine receptor in macrophages. 43rd UIPAC World Chemistry Congress, Puerto Rico Convention Center, PR, July 30, 2011.

Grajales-Reyes Gary E, Céspedes Katty, Madera Bismark, Ramirez Rosaura, Gómez Christopher and Lasalde-Dominicci José A. Degeneration of the neuromuscular junction of a congenital myasthenic syndrome via cholesterol-reducing treatment; a transgenic mice study of the aC418W novel mutation. – 4th RISE Area Conference University of Puerto Rico 2007

Grajales-Reyes Gary E, Haipeng Zhu, Báez-Pagán Carlos A., Quesada Orestes, Grajales-Reyes Jose G., Delgado Manuel, Ramírez Rosaura, Gómez Christopher and Lasalde-Dominicci José A. Lipid-protein interaction studies in the aC418W slow channel congenital myasthenic syndrome.: - Annual Biomedical Research Convention For Minority Students (ABRCMS) 2008 & 2009- Society for Neuroscience Meeting 2008 & 2009

Madera Bismarck, Ortiz Acevedo A., Galloza J.C., Quintana R.E., Martinez H.L, Lasalde-Dominicci J.A. Lateral Diffusion Of The Torpedo Californica Acetilcholine Receptor In Oocyte Membrane - 42nd ACS Junior Technical Meeting 27th Puerto Rico Interdisiplinary Scientific Meeting (PRISM) March 10, 2007.   

del Hoyo Rivera Natalie. Modulation of the a 7 neuronal nicotinic acetylcholine receptor by cholestero - The 15th Annual Puerto Rico Neuroscience Conference December 2, 2006.

del Hoyo Rivera Natalie. Modulation of the a 7 neuronal nicotinic acetylcholine receptor by cholesterol - The 10th RCMI International Symposium December 15, 2006. Annual Biomedical Research Conference for Minority Students Symposium November 8, 2007. Experimental Biology Symposium April 7, 2008Annual Biomedical Research Conference for Minority Students Symposium. November 8, 2008. PRISM 2010 March 13, 2010. Fifth Transdisciplinary Research Conference 2010 May 13-14, 2010.

Natalie del Hoyo Rivera., Modulation of the Nicotinic Acetylcholine Receptor Function by Cholesterol - Annual Best Practices Conference on Teaching and Learning October 29, 2010. AAAS Annual Conference September 25, 2010. Biophysical Society Annual Meeting 2011 March 5-9, 2011.

Oyola-Cintrón, Jessica; Caballero-Rivera, Daniel; García-Matos, Jomarie; Cruz-Nieves, Omar A.; Lasalde-Dominicci, José A. Role of Lipid-Exposed Residues on the Function and Dynamics of the Muscle-Type Nicotinic Acetylcholine Receptor.-The 41th ACS Junior Technical Meeting, Cayey, PR, 2006.

Santiago-Pérez, Laura I., García-Matos, Jomarie; Caballero-Rivera, Daniel; Cruz-Nieves, Omar A.; Oyola-Cintrón, Jessica; and Lasalde-Dominicci, José A. Incorporation of Unnatural Amino Acids into a4b2 Neuronal Nicotinic Acetylcholine Receptors (nAChRs) in HEK 293.-15th Puerto Rico Neuroscience Conference, Bayamón, PR; 2006

Caballero-Rivera, Daniel; Cruz-Nieves, Omar A.; Santiago-Pérez, Laura I., García-Matos, Jomarie; Oyola-Cintrón, Jessica; and Lasalde-Dominicci, José A. Incorporation of Fluorescent Unnatural Amino Acids into Torpedo califirnica and Neuronal Nicotinic Acetylcholine Receptors. -10th RCMI Internacional Symposium, San Juan, PR; 2006. 41st IUPAC Congress, Torino, Italy; 2007

Jessica Oyola-Cintrón, Daniel Caballero-Rivera, Leomar Ballester, Karla Vélez-Arroyo, Jomarie García-Matos, Leonardo Martínez, Carlos J. Nogueras, Orestes Quesada, José García, Walter I. Silva, José A. Lasalde-Dominicci. Role of Membrane Cholesterol Levels in the Lateral Diffusion and Function of the Novel Slow Channel Congenital Myasthenic Syndrome aC418W AChR Mutant. - 17th Puerto Rico Neuroscience Conference, San Juan, PR; 2008. Biophysical Society 53rd Annual Meeting, Boston, MA; 2009

Jessica Oyola-Cintrón, Daniel Caballero-Rivera, Leomar Ballester, Leonardo Martínez, Carlos J. Nogueras, Carlos Baéz-Pagán, Orestes Quesada, José A. Lasalde-Dominicci. Potential implications of cholesterol and phosphatidylinositol 4,5-bisphosphate (PIP2) interactions with the cholesterol-sensitive aC418W AChR mutation at lipid rafts. - Biophysical Society 54th Annual Meeting, San Francisco, CA; 2010. 7th Annual Area Conference, San Juan, PR; 2011

Jessica Oyola-Cintrón, Daniel Caballero-Rivera, Leomar Ballester, Leonardo Martínez, Carlos J. Nogueras, Carlos Baéz-Pagán, Orestes Quesada, José A. Lasalde-Dominicci. Elucidating the role of the lipid-protein interface in regulating the functional pool of AChRs in a novel SCCMS. - Specialized Neuroscience Research Program (SNRP), San Juan, PR; 2010

Capó, Coral; Santiago, Eduardo; Delgado, Manuel; Nogueras, Carlos; Meléndez, Roberto and Lasalde, José. alpha 7-nicotinic acetylcholine receptors are up-regulated after exposure to HIV-1 gp120: potential implications in the pathogenesis of HIV-1 associated dementia." University of Puerto Rico, Rio Piedras Campus, San Juan, Puerto Rico. 44th Junior Technical Meeting, San Juan, Puerto Rico, March 14, 2009. 9th  International Symposium for Neurovirology. Miami, Florida. June 2-6, 2009. University of Puerto Rico, Rio Piedras Campus, San Juan, Puerto Rico. Society for Neuroscience Annual Meeting, Chicago, Illinois, October 16-21, 2009. 10th International Society for NeuroVirology Meeting, Milan, Italy, October 12-16, 2010

C.M. Capó-Vélez1 E. Santiago-Montes, M. Delgado-Vélez, & J.A. Lasalde-Dominicci. Upregulation of a7-nicotinic receptors by HIV-1 gp120: implications in the pathogenesis of HIV associated dementia. 8th Conference of the Specialized Neuroscience Research Programs, Caribe Hilton, San Juan, Puerto Rico, July 21-23, 2010

Capó, Coral; Santiago, Eduardo; Delgado, Manuel; Nogueras, Carlos; Meléndez, Roberto and Lasalde, José. a7-nicotinic acetylcholine receptors are upregulated in a HIV-1 gp120-transgenic mice model. 19th Annual Puerto Rico Neuroscience Conference, Interamerican University, PR, December 4, 2010. RISE Area Conference, Verdanza Hotel, Isla Verde, March 18-19, 2011

Capó-Vélez, Coral; Delgado, Manuel; Meléndez, Roberto; Lasalde-Dominicci, J. a7-nicotinic acetylcholine receptors are upregulated in a transgenic mouse model that expresses the HIV-1 coat protein gp120. Society for Neuroscience Annual Meeting, November 12-17, 2011, Washington, D.C. Puerto Rico Neuroscience meeting, December 3, 2011, San Juan, Puerto Rico